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*Refers to actual injection time of PHESGO vs infusion time of IV PERJETA + trastuzumab and does not account for all aspects of treatment. Actual clinic time may vary. PERJETA and trastuzumab can be given in any order.1,2 Please see the PERJETA full Prescribing Information for additional dosing information for PERJETA + trastuzumab.
Patients currently receiving IV PERJETA + trastuzumab can be transitioned to PHESGO if eligible.1
PHESGO is FDA approved for all of the same HER2+ breast cancer indications as PERJETA.1,2
†In early breast cancer, patients who begin PHESGO-based therapy in the neoadjuvant setting should receive 3-6 cycles before surgery and should continue treatment after surgery, every 3 weeks, to complete 1 year (up to 18 cycles). Patients who begin treatment in the adjuvant setting should receive a total of 1 year (up to 18 cycles) of PHESGO-based therapy, every 3 weeks, starting on Day 1 of the first taxane-containing cycle.1
NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) state that pertuzumab, trastuzumab, and hyaluronidase-zzxf injection for subcutaneous use (PHESGO) may be substituted anywhere that IV pertuzumab (PERJETA) + trastuzumab are given as part of systemic therapy for HER2+ breast cancer.‡3
‡Pertuzumab, trastuzumab, and hyaluronidase-zzxf injection for subcutaneous use (PHESGO) has different dosing and administration instructions compared to the intravenous products.
Interested in more information about PHESGO? Fill out this form to connect with a Genentech representative.
PHESGO Prescribing Information. Genentech, Inc. 2020.
PHESGO Prescribing Information. Genentech, Inc. 2020.
PERJETA Prescribing Information. Genentech, Inc. 2021.
PERJETA Prescribing Information. Genentech, Inc. 2021.
Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Breast Cancer V2.2022. © National Comprehensive Cancer Network, Inc. 2022. All rights reserved. Accessed January 21, 2022. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.
Referenced with permission from the NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) for Breast Cancer V2.2022. © National Comprehensive Cancer Network, Inc. 2022. All rights reserved. Accessed January 21, 2022. To view the most recent and complete version of the guideline, go online to NCCN.org. NCCN makes no warranties of any kind whatsoever regarding their content, use or application and disclaims any responsibility for their application or use in any way.
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